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  • PMID: 25508110 was deleted because it is a duplicate of PMID: 25438579
Zh Vyssh Nerv Deiat Im I P Pavlova. 2013 Sep-Oct;63(5):507-19.

[Role of glycogen synthase kinase-3 in mechanisms of learning and memory].

[Article in Russian]


In the current paper a review of the role of GSK-3b in mechanisms of learning and memory is presented. A regulation of GSK-3 by phosphorylation of serine and tyrosine sites and through Wnt signaling pathway by disruption of axin-β-catenin complex is described. The data on participation of GSK-3b in regulation of NMDA-dependent long-term depression and potentiation, and the possible mechanisms of enzyme's influence through NMDA receptors and AMPA endocytosis are shown. A role of GSK-3b in development of Alzheimer's disease through inhibition of Wnt signaling parthway by beta-amyloid resulting in a strengthening of GSK-3b activity with further hyperphosphorylation of tay and formation of the neurofibrillary complexes are also considered. Behaviour of animals with knockout and overexpression of GSK-3b gene and effects of GSK-3 inhibitors in different behavioural models are also described.

[Indexed for MEDLINE]

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