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Mol Biol Int. 2014;2014:686984. doi: 10.1155/2014/686984. Epub 2014 Nov 20.

mTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic Interventions.

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1
Department of Biotechnology and Bioinformatics, University of Kashmir, Science Block, Ground Floor, Srinagar, Jammu and Kashmir 190006, India.

Abstract

mTOR is a central nutrient sensor that signals a cell to grow and proliferate. Through distinct protein complexes it regulates different levels of available cellular energy substrates required for cell growth. One of the important functions of the complex is to maintain available amino acid pool by regulating protein translation. Dysregulation of mTOR pathway leads to aberrant protein translation which manifests into various pathological states. Our review focuses on the role mTOR signaling plays in protein translation and its physiological role. It also throws some light on available data that show translation dysregulation as a cause of pathological complexities like cancer and the available drugs that target the pathway for cancer treatment.

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