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J Virol. 2015 Mar;89(5):2956-61. doi: 10.1128/JVI.02721-14. Epub 2014 Dec 10.

Virion-independent transfer of replication-competent hepatitis C virus RNA between permissive cells.

Author information

1
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA fchisari@scripps.edu andrea.longatti@alumni.ethz.ch.
2
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.

Abstract

In this study, we show that replication-competent subgenomic hepatitis C virus (HCV) RNA can be transferred to permissive Huh7 cells, leading to the establishment of viral RNA replication. Further, we show that these events are mediated by exosomes rather than infectious virus particles. If similar events occur in vivo, this could represent a novel, albeit inefficient, mechanism of viral spread and immune escape.

PMID:
25505060
PMCID:
PMC4325714
DOI:
10.1128/JVI.02721-14
[Indexed for MEDLINE]
Free PMC Article

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