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Chem Commun (Camb). 2015 Jan 31;51(9):1666-9. doi: 10.1039/c4cc08227c.

One-by-one single-molecule detection of mutated nucleobases by monitoring tunneling current using a DNA tip.

Author information

1
Department of Materials Science, Osaka Prefecture University, Sakai, Osaka 599-8570, Japan.

Abstract

A DNA molecule was utilized as a probe tip to achieve single-molecule genetic diagnoses. Hybridization of the probe and target DNAs resulted in electron tunneling along the emergent double-stranded DNA. Simple stationary monitoring of the tunneling current leads to single-molecule DNA detection and discovery of base mismatches and methylation.

PMID:
25503307
DOI:
10.1039/c4cc08227c
[Indexed for MEDLINE]

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