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Anticancer Res. 2014 Dec;34(12):6939-44.

Evaluation of a special combination of glucan with organic selenium derivative in different murine tumor models.

Author information

1
Department of Pathology, University of Louisville, Louisville, KY, U.S.A. vaclav.vetvicka@louisville.edu.
2
Department of Fundamental Chemistry/Institute of Chemistry, University of São Paulo, São Paulo, SP, Brazil.
3
Department of Research and Development, Biorigin Company, Lençóis Paulista, SP, Brazil.

Abstract

β-glucans are well-established immunomodulators with strong effects resulting in slowing or even inhibiting cancer growth. Recent studies have repeatedly suggested that the biological activities of β-glucan can be potentiated by the addition of other bioactive agents. In the current study, we focused on the anticancer effects of a combination of yeast-derived β-glucan and a selenium-linked pseudodisaccharide. Using three different models of murine cancer, we showed that this combination strongly suppressed the growth of all three types of cancers, most likely via the interaction with natural anticancer antibodies.

KEYWORDS:

Glucan; breast cancer; cancer; immunity; lung cancer; organic selenium

PMID:
25503119
[Indexed for MEDLINE]

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