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Am J Physiol Regul Integr Comp Physiol. 2015 Feb 1;308(3):R199-207. doi: 10.1152/ajpregu.00422.2014. Epub 2014 Dec 10.

The truncated TrkB receptor influences mammalian sleep.

Author information

1
Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;
2
School of Nursing, University of Maryland, Baltimore, Maryland; and.
3
College of Medical Sciences, Sleep and Performance Research Center, Washington State University Spokane, Spokane, Washington marcos.frank@wsu.edu.

Abstract

Brain-derived neurotrophic factor (BDNF) is a neurotrophin hypothesized to play an important role in mammalian sleep expression and regulation. In order to investigate the role of the truncated receptor for BDNF, TrkB.T1, in mammalian sleep, we examined sleep architecture and sleep regulation in adult mice constitutively lacking this receptor. We find that TrkB.T1 knockout mice have increased REM sleep time, reduced REM sleep latency, and reduced sleep continuity. These results demonstrate a novel role for the TrkB.T1 receptor in sleep expression and provide new insights into the relationship between BDNF, psychiatric illness, and sleep.

KEYWORDS:

REM sleep; TrkB; TrkB.T1; brain-derived neurotrophic factor; neurotrophins

PMID:
25502751
PMCID:
PMC4313071
DOI:
10.1152/ajpregu.00422.2014
[Indexed for MEDLINE]
Free PMC Article

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