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Curr Protoc Bioinformatics. 2014 Dec 12;48:3.13.1-16. doi: 10.1002/0471250953.bi0313s48.

Clustal omega.

Author information

1
School of Medicine and Medical Science, Conway Institute, University College Dublin, Ireland.

Abstract

Clustal Omega is a package for making multiple sequence alignments of amino acid or nucleotide sequences, quickly and accurately. It is a complete upgrade and rewrite of earlier Clustal programs. This unit describes how to run Clustal Omega interactively from a command line, although it can also be run online from several sites. The unit describes a basic protocol for taking a set of unaligned sequences and producing a full alignment. There are also protocols for using an external HMM or iteration to help improve an alignment.

KEYWORDS:

Clustal Omega; HMM; hidden Markov model; iteration; multiple sequence alignment

PMID:
25501942
DOI:
10.1002/0471250953.bi0313s48
[Indexed for MEDLINE]

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