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J Acquir Immune Defic Syndr. 2015 Apr 1;68(4):420-4. doi: 10.1097/QAI.0000000000000480.

Immunologic, virologic, and pharmacologic characterization of the female upper genital tract in HIV-infected women.

Author information

1
*Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC; †Center for AIDS Research, University of North Carolina, Chapel Hill, NC; ‡Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC; §Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC; and ‖Health Sciences Center, University of Tennessee Health, Memphis, TN.

Abstract

: A comparative analysis of cellular and soluble markers of immune activation in HIV-infected women on combination antiretroviral therapy showed that the upper genital tract (UGT) compared to the lower female genital tract was characterized by higher frequencies of potential HIV target cells and increased inflammatory molecules. Despite the activated UGT milieu, HIV RNA could not be detected in paired samples of plasma, cervicovaginal or endometrial lavage. As antiretroviral concentrations were ≥3-fold higher in the endometrium than in the lower genital tract, high antiretroviral penetration and/or metabolism may limit viral replication in the UGT.

PMID:
25501615
PMCID:
PMC4334681
DOI:
10.1097/QAI.0000000000000480
[Indexed for MEDLINE]
Free PMC Article

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