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PLoS One. 2014 Dec 12;9(12):e114790. doi: 10.1371/journal.pone.0114790. eCollection 2014.

Wild blueberries (Vaccinium myrtillus) alleviate inflammation and hypertension associated with developing obesity in mice fed with a high-fat diet.

Author information

1
Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, Food and Health Research Centre, University of Eastern Finland, Kuopio, Finland.
2
Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
3
Institute of Biomedicine and Biocenter of Oulu, University of Oulu, Medical Center Oulu and Oulu University Hospital, Oulu, Finland.
4
Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, Food and Health Research Centre, University of Eastern Finland, Kuopio, Finland; Department of Environmental Health, National Institute for Health and Welfare, Kuopio, Finland.

Abstract

BACKGROUND:

Low-grade metabolic inflammation and hypertension are primary mechanisms involved in obesity-associated adverse health effects. Berries, especially Nordic wild blueberries (hereafter referred to as bilberries), represent an important source of dietary anthocyanins, a group of polyphenols with potential beneficial effects to combat obesity-associated metabolic disturbances.

METHODS:

The effects of 5% or 10% (w/w) of whole bilberries (BB) were studied on the development of obesity and its metabolic disturbances in C57BL mice fed with a high-fat diet (HFD) for three months. Cytokines, inflammatory cells, systolic blood pressure, glucose tolerance, insulin sensitivity, weight gain, body fat, food consumption and energy metabolism were assessed.

RESULTS:

Bilberries ameliorated type 1 pro-inflammatory responsiveness induced by HFD. This was indicated by the altered cytokine profile and the reduced prevalence of interferon gamma -producing T-cells, in particular T helper type 1 cells. Bilberries also prevented the progression of obesity associated long term increase in systolic blood pressure in mice.

CONCLUSIONS:

Bilberries reduce the development of systemic inflammation and prevent the progression of chronic hypertension, thus supporting their potential role in alleviating the adverse health effects associated with developing obesity.

PMID:
25501421
PMCID:
PMC4264776
DOI:
10.1371/journal.pone.0114790
[Indexed for MEDLINE]
Free PMC Article

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