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J Clin Lipidol. 2014 Nov-Dec;8(6):612-7. doi: 10.1016/j.jacl.2014.08.001. Epub 2014 Aug 19.

Purified palmitoleic acid for the reduction of high-sensitivity C-reactive protein and serum lipids: a double-blinded, randomized, placebo controlled study.

Author information

1
Wellness Institute, Cleveland Clinic, Lyndhurst, OH, USA. Electronic address: bernsta2@ccf.org.
2
Wellness Institute, Cleveland Clinic, Lyndhurst, OH, USA.
3
Xyrion Medical Institute, Ponce, PR, USA.

Abstract

BACKGROUND:

Purified palmitoleic acid (16-1; omega-7) has shown lipid-lowering and anti-inflammatory benefits in open label, epidemiologic, and animal studies.

OBJECTIVE:

Our objective was to perform the first randomized controlled trial of purified palmitoleic acid supplementation in humans.

METHODS:

Adults with dyslipidemia and evidence of mild systemic inflammation (high-sensitivity C-reactive protein [hs-CRP] between 2 and 5 mg/L) were randomly allocated to receive either 220.5 mg of cis-palmitoleic acid (n = 30) or an identical capsule with placebo (1000 mg of medium chain triglycerides, n = 30) once per day for 30 days. Participants were asked to maintain their current diet. Serum lipids and hs-CRP were drawn at baseline and study completion.

RESULTS:

At 30 days, there were significant mean (95% confidence interval [CI]) reductions in CRP (-1.9 [-2.3 to -1.4] mg/L), triglyceride (-30.2 [-40.2 to -25.3] mg/dL), and low-density lipoprotein (LDL) (-8.9 [-12.0 to -5.8] mg/dL), and a significant increase in high-density lipoprotein (HDL) (2.4 [1.5, 3.3] mg/dL) in the intervention group compared with control. These changes equated to 44%, 15%, and 8% reductions in CRP, triglyceride, and LDL respectively, and a 5% increase in HDL compared with control.

CONCLUSIONS:

Purified palmitoleic acid may be useful in the treatment of hypertriglyceridemia with the beneficial added effects of decreasing LDL and hs-CRP and raising HDL. Further study is needed to elucidate mechanisms and establish appropriate human doses.

KEYWORDS:

C-reactive protein; Cholesterol; Hyperlipidemia; Inflammation; Lipids; Omega-7; Palmitoleate; Palmitoleic acid; Supplementation

PMID:
25499944
DOI:
10.1016/j.jacl.2014.08.001
[Indexed for MEDLINE]
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