Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2015 Jan 15;25(2):167-71. doi: 10.1016/j.bmcl.2014.11.051. Epub 2014 Nov 26.

Isotope chemistry; a useful tool in the drug discovery arsenal.

Author information

1
Isotope Chemistry, DMPK, AstraZeneca Pharmaceuticals, 43183 Mölndal, Sweden.
2
Isotope Chemistry, DMPK, AstraZeneca Pharmaceuticals, Alderley Park, UK.

Abstract

As Medicinal Chemists are responsible for the synthesis and optimization of compounds, they often provide intermediates for use by isotope chemistry. Nevertheless, there is generally an incomplete understanding of the critical factors involved in the labeling of compounds. The remit of an Isotope Chemistry group varies from company to company, but often includes the synthesis of compounds labeled with radioisotopes, especially H-3 and C-14 and occasionally I-125, and stable isotopes, especially H-2, C-13, and N-15. Often the remit will also include the synthesis of drug metabolites. The methods used to prepare radiolabeled compounds by Isotope Chemists have been reviewed relatively recently. However, the organization and utilization of Isotope Chemistry has not been discussed recently and will be reviewed herein.

KEYWORDS:

C-14; Isotope chemistry; Isotopic labeling; Tritium

PMID:
25499878
DOI:
10.1016/j.bmcl.2014.11.051
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center