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Adv Drug Deliv Rev. 2015 Apr;84:257-77. doi: 10.1016/j.addr.2014.11.022. Epub 2014 Dec 10.

The past, present and future in scaffold-based tendon treatments.

Author information

1
Network of Excellence for Functional Biomaterials (NFB), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland.
2
Veterinary Faculty, University of Thessaly, Karditsa, Greece.
3
Animal Production Division, Department of Agriculture Technology, TEI of Epirus, Arta, Greece.
4
Department of Physiology, NUI Galway, Ireland.
5
College of Engineering and Informatics, NUI Galway, Galway, Ireland.
6
Teagasc Research Centre, Ashtown, Ireland.
7
Network of Excellence for Functional Biomaterials (NFB), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland; Department of Surgery, NUI Galway, Galway, Ireland.
8
Network of Excellence for Functional Biomaterials (NFB), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland; University College Hospitals Galway (UCHG), Galway, Ireland.
9
Network of Excellence for Functional Biomaterials (NFB), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland. Electronic address: dimitrios.zeugolis@nuigalway.ie.

Abstract

Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent, especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics/biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come.

KEYWORDS:

Biomaterials; Human and equine tendon injury; Sustained and localised delivery of therapeutics/biologics; Tendon cellular and extracellular composition; Tendon healing; Tissue grafts

PMID:
25499820
DOI:
10.1016/j.addr.2014.11.022
[Indexed for MEDLINE]

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