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Trends Plant Sci. 2015 Feb;20(2):124-33. doi: 10.1016/j.tplants.2014.11.004. Epub 2014 Dec 8.

Molecular mechanisms governing Arabidopsis iron uptake.

Author information

  • 1Institute of Botany, Heinrich-Heine University, Universitätstrasse 1, D-40225 Düsseldorf, Germany.
  • 2Institute of Botany, Heinrich-Heine University, Universitätstrasse 1, D-40225 Düsseldorf, Germany; Cluster of Excellence on Plant Sciences (CEPLAS), Heinrich-Heine University, D-40225 Düsseldorf, Germany.
  • 3Institute of Botany, Heinrich-Heine University, Universitätstrasse 1, D-40225 Düsseldorf, Germany. Electronic address: rumen.ivanov@uni-duesseldorf.de.

Abstract

Plants are the principal source of dietary iron (Fe) for most of Earth's population and Fe deficiency can lead to major health problems. Developing strategies to improve plant Fe content is a challenge because Fe is essential and toxic and therefore regulating Fe uptake is crucial for plant survival. Acquiring soil Fe relies on complex regulatory events that occur in root epidermal cells. We review recent advances in elucidating many aspects of the regulation of Fe acquisition. These include the expanding protein network involved in FER-LIKE IRON DEFICIENCY INDUCED TRANSCRIPTION FACTOR (FIT)-dependent gene regulation and novel findings on the intracellular trafficking of the Fe transporter IRON-REGULATED TRANSPORTER 1 (IRT1). We outline future challenges and propose strategies, such as exploiting natural variation, to further expand our knowledge.

KEYWORDS:

IRT1 trafficking; iron uptake; phytohormones; transcriptional regulation

PMID:
25499025
DOI:
10.1016/j.tplants.2014.11.004
[PubMed - indexed for MEDLINE]
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