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Life Sci. 2015 Jan 15;121:97-103. doi: 10.1016/j.lfs.2014.11.030. Epub 2014 Dec 11.

The role of Pyruvate Dehydrogenase Complex in cardiovascular diseases.

Author information

1
Division of Cardiovascular Medicine, The First Hospital of Jilin University, Changchun 130021, China.
2
Division of Cardiovascular Medicine, The First Hospital of Jilin University, Changchun 130021, China. Electronic address: jli23@jlu.edu.cn.

Abstract

The regulation of mammalian myocardial carbohydrate metabolism is complex; many factors such as arterial substrate and hormone levels, coronary flow, inotropic state and the nutritional status of the tissue play a role in regulating mammalian myocardial carbohydrate metabolism. The Pyruvate Dehydrogenase Complex (PDHc), a mitochondrial matrix multienzyme complex, plays an important role in energy homeostasis in the heart by providing the link between glycolysis and the tricarboxylic acid (TCA) cycle. In TCA cycle, PDHc catalyzes the conversion of pyruvate into acetyl-CoA. This review determines that there is altered cardiac glucose in various pathophysiological states consequently causing PDC to be altered. This review further summarizes evidence for the metabolism mechanism of the heart under normal and pathological conditions including ischemia, diabetes, hypertrophy and heart failure.

KEYWORDS:

Glucose metabolism; Heart disease; Pyruvate Dehydrogenase Complex

PMID:
25498896
DOI:
10.1016/j.lfs.2014.11.030
[Indexed for MEDLINE]

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