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Microbes Infect. 2015 Feb;17(2):118-22. doi: 10.1016/j.micinf.2014.11.010. Epub 2014 Dec 11.

Genetic tuning of avian influenza A (H7N9) virus promotes viral fitness within different species.

Author information

1
Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Key Laboratory of Surveillance and Early Warning on Infectious Disease, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Beijing 102206, PR China.
2
Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Key Laboratory of Surveillance and Early Warning on Infectious Disease, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Beijing 102206, PR China. Electronic address: yshu@cnic.org.cn.

Abstract

Since their emergence in eastern China, novel influenza A (H7N9) viruses have been continuously circulating in poultry and causing human infections and death. We have proposed a "genetic tuning" mechanism for the genesis and evolution of the novel H7N9 virus during interspecies transmission.

KEYWORDS:

Avian influenza A (H7N9) virus; Genetic tuning; Potential hosts

PMID:
25498867
DOI:
10.1016/j.micinf.2014.11.010
[Indexed for MEDLINE]

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