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Brain Res. 2015 Feb 9;1597:220-46. doi: 10.1016/j.brainres.2014.11.059. Epub 2014 Dec 8.

Pathways of polyunsaturated fatty acid utilization: implications for brain function in neuropsychiatric health and disease.

Author information

1
Department of Molecular Imaging & Neuropathology, New York State Psychiatric Institute, New York, NY, USA; New York Medical College, Valhalla, NY, USA.
2
Laboratory of Metabolic Research, Felsenstein Medical Research Center, Tel Aviv University, Petach Tikva, Israel.
3
Department of Molecular Imaging & Neuropathology, New York State Psychiatric Institute, New York, NY, USA; Department of Psychiatry, Columbia University, New York, NY, USA; Department of Radiology, Columbia University, New York, NY, USA.
4
Brain Physiology and Metabolism Section, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
5
Department of Molecular Imaging & Neuropathology, New York State Psychiatric Institute, New York, NY, USA; Department of Psychiatry, Columbia University, New York, NY, USA. Electronic address: es2316@columbia.edu.

Abstract

Essential polyunsaturated fatty acids (PUFAs) have profound effects on brain development and function. Abnormalities of PUFA status have been implicated in neuropsychiatric diseases such as major depression, bipolar disorder, schizophrenia, Alzheimer's disease, and attention deficit hyperactivity disorder. Pathophysiologic mechanisms could involve not only suboptimal PUFA intake, but also metabolic and genetic abnormalities, defective hepatic metabolism, and problems with diffusion and transport. This article provides an overview of physiologic factors regulating PUFA utilization, highlighting their relevance to neuropsychiatric disease.

KEYWORDS:

Bipolar disorder; Brain; Depression; Lipid metabolism; Polyunsaturated fatty acids; Schizophrenia

PMID:
25498862
PMCID:
PMC4339314
DOI:
10.1016/j.brainres.2014.11.059
[Indexed for MEDLINE]
Free PMC Article

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