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Diagn Microbiol Infect Dis. 2015 Feb;81(2):141-4. doi: 10.1016/j.diagmicrobio.2014.10.004. Epub 2014 Nov 28.

Carriage niches and molecular epidemiology of Staphylococcus lugdunensis and methicillin-resistant S. lugdunensis among patients undergoing long-term renal replacement therapy.

Author information

1
Carol Yu Centre for Infection and Department of Microbiology, Queen Mary Hospital, University of Hong Kong, Hong Kong, China. Electronic address: plho@hkucc.hku.hk.
2
Carol Yu Centre for Infection and Department of Microbiology, Queen Mary Hospital, University of Hong Kong, Hong Kong, China.
3
Department of Clinical Pathology, Kwong Wah Hospital, Hong Kong, China.
4
Department of Medicine and Geriatrics, Kwong Wah Hospital, Hong Kong, China.
5
Department of Medicine, Tung Wah Hospital, Hong Kong, China.

Abstract

We collected nasal, axilla, and groin swabs from 252 adult patients from 2 nephrology centers in Hong Kong. Staphylococcus lugdunensis carriage was detected in 51.6% patients (groin, 39.3%; axilla, 19.8%; nose, 17.9%). The carriage rates of methicillin-sensitive S. lugdunensis and methicillin-resistant S. lugdunensis (MRSL) were 46.0% and 8.3%, respectively. Independent risk factors for S. lugdunensis carriage included male sex (odds ratio [OR], 4.4), hemodialysis (OR, 2.2), and aged 18-50years (OR, 2.4). The isolates belonged to 10 pulsotype clusters (n=129) and 8 singletons (n=8). All MRSL and most gentamicin- and tetracycline-resistant strains were found in a predominating sequence type 3 clone, designated HKU1, which accounted for 51.8% of all colonizing S. lugdunensis strains. The 21 MRSL isolates had SCCmec type V (n=18), type IV (n=2), and type I (n=1). The finding highlights the potential for dissemination of multidrug resistance through successful S. lugdunensis clones.

KEYWORDS:

Antimicrobial resistance; Methicillin resistance; Molecular epidemiology; Renal replacement therapy; Staphylococcus lugdunensis

[Indexed for MEDLINE]

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