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Psychoneuroendocrinology. 2015 Feb;52:229-38. doi: 10.1016/j.psyneuen.2014.11.014. Epub 2014 Nov 22.

Anticipatory sensitization to repeated stressors: the role of initial cortisol reactivity and meditation/emotion skills training.

Author information

1
Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: bturanb@uab.edu.
2
Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA.
3
Department of Psychology, University of New Mexico, Albuquerque, NM 87131, USA.
4
Santa Barbara Institute for Consciousness Studies, Santa Barbara, CA 93130, USA.
5
Center for Mind and Brain, University of California at Davis, Davis, CA 95618, USA.
6
Curry School of Education, University of Virginia, Charlottesville, CA 22904, USA.

Abstract

Anticipation may play a role in shaping biological reactions to repeated stressors-a common feature of modern life. We aimed to demonstrate that: (a) individuals who display a larger cortisol response to an initial stressor exhibit progressive anticipatory sensitization, showing progressively higher cortisol levels before subsequent exposures, and (b) attention/emotional skills training can reduce the magnitude of this effect on progressive anticipatory sensitization. Female school teachers (N=76) were randomly assigned to attention/emotion skills and meditation training or to a control group. Participants completed 3 separate Trier Social Stress Tests (TSST): at baseline (Session 1), post-training (Session 2), and five months post (Session 3). Each TSST session included preparing and delivering a speech and performing an arithmetic task in front of critical evaluators. In each session participants' salivary cortisol levels were determined before and after the stressor. Control participants with larger cortisol reactivity to the first stressor showed increasing anticipatory (pre-stressor) cortisol levels with each successive stressor exposure (TSST session)-suggesting progressive anticipatory sensitization. Yet this association was absent in the training group. Supplementary analyses indicated that these findings occurred in the absence of group differences in cortisol reactivity. Findings suggest that the stress response can undergo progressive anticipatory sensitization, which may be modulated by attention/emotion-related processes. An important implication of the construct of progressive anticipatory sensitization is a possible self-perpetuating effect of stress reactions, providing a candidate mechanism for the translation of short-to-long-term stress reactions.

KEYWORDS:

Anticipation; Cortisol; Emotional training; HPA axis; Meditation; Sensitization; Stress

PMID:
25497480
DOI:
10.1016/j.psyneuen.2014.11.014
[Indexed for MEDLINE]

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