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Trends Endocrinol Metab. 2015 Feb;26(2):69-74. doi: 10.1016/j.tem.2014.11.004. Epub 2014 Dec 9.

Effects of the gut microbiota on bone mass.

Author information

1
Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden.
2
Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden. Electronic address: klara.sjogren@medic.gu.se.

Abstract

The gut microbiota (GM), the commensal bacteria living in our intestine, performs numerous useful functions, including modulating host metabolism and immune status. Recent studies demonstrate that the GM is also a regulator of bone mass and it is proposed that the effect of the GM on bone mass is mediated via effects on the immune system, which in turn regulates osteoclastogenesis. Under normal conditions, the skeleton is constantly remodeled by bone-forming osteoblasts (OBs) and bone-resorbing osteoclasts (OCLs), and imbalances in this process may lead to osteoporosis. Here we review current knowledge on the possible role for the GM in the regulation of bone metabolism and propose that the GM might be a novel therapeutic target for osteoporosis and fracture prevention.

KEYWORDS:

gut microbiota; osteoimmunology; osteoporosis

PMID:
25497348
DOI:
10.1016/j.tem.2014.11.004
[Indexed for MEDLINE]

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