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Br J Haematol. 2015 Apr;169(1):14-31. doi: 10.1111/bjh.13254. Epub 2014 Dec 11.

The genomic landscape of chronic lymphocytic leukaemia: biological and clinical implications.

Author information

1
Cancer Genomics, Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

Abstract

Chronic lymphocytic leukaemia (CLL) remains at the forefront of the genetic analysis of human tumours, principally due its prevalence, protracted natural history and accessibility to suitable material for analysis. With the application of high-throughput genetic technologies, we have an unbridled view of the architecture of the CLL genome, including a comprehensive description of the copy number and mutational landscape of the disease, a detailed picture of clonal evolution during pathogenesis, and the molecular mechanisms that drive genomic instability and therapeutic resistance. This work has nuanced the prognostic importance of established copy number alterations, and identified novel prognostically relevant gene mutations that function within biological pathways that are attractive treatment targets. Herein, an overview of recent genomic discoveries will be reviewed, with associated biological and clinical implications, and a view into how clinical implementation may be facilitated.

KEYWORDS:

chronic lymphocytic leukaemia; clinical aspects; genetic analysis; prognostic factors

PMID:
25496136
DOI:
10.1111/bjh.13254
[Indexed for MEDLINE]

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