Format

Send to

Choose Destination
See comment in PubMed Commons below
Electromagn Biol Med. 2016;35(1):65-74. doi: 10.3109/15368378.2014.987923. Epub 2014 Dec 11.

The developmental effects of extremely low frequency electric fields on visual and somatosensory evoked potentials in adult rats.

Author information

  • 1a Department of Biophysics , Faculty of Medicine, Akdeniz University , Antalya , Turkey .
  • 2b Department of Electrical and Electronics Engineering , Engineering Faculty, Akdeniz University , Antalya , Turkey , and.
  • 3c Department of Physiology , Faculty of Medicine, Akdeniz University , Antalya , Turkey.

Abstract

The purpose of our study was to investigate the developmental effects of extremely low frequency electric fields (ELF-EFs) on visual evoked potentials (VEPs) and somatosensory-evoked potentials (SEPs) and to examine the relationship between lipid peroxidation and changes of these potentials. In this context, thiobarbituric acid reactive substances (TBARS) levels were determined as an indicator of lipid peroxidation. Wistar albino female rats were divided into four groups; Control (C), gestational (prenatal) exposure (Pr), gestational+ postnatal exposure (PP) and postnatal exposure (Po) groups. Pregnant rats of Pr and PP groups were exposed to 50 Hz electric field (EF) (12 kV/m; 1 h/day), while those of C and Po groups were placed in an inactive system during pregnancy. Following parturition, rats of PP and Po groups were exposed to ELF-EFs whereas rats of C and Pr groups were kept under the same experimental conditions without being exposed to any EF during 68 days. On postnatal day 90, rats were prepared for VEP and SEP recordings. The latencies of VEP components in all experimental groups were significantly prolonged versus C group. For SEPs, all components of PP group, P2, N2 components of Pr group and P1, P2, N2 components of Po group were delayed versus C group. As brain TBARS levels were significantly increased in Pr and Po groups, retina TBARS levels were significantly elevated in all experimental groups versus C group. In conclusion, alterations seen in evoked potentials, at least partly, could be explained by lipid peroxidation in the retina and brain.

KEYWORDS:

Developmental period; electric field; lipid peroxidation; somatosensory evoked potentials; visual evoked potentials

PMID:
25496054
DOI:
10.3109/15368378.2014.987923
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis
    Loading ...
    Support Center