The potential of 12/15-lipoxygenase inhibitors in stroke therapy

Future Med Chem. 2014;6(17):1853-5. doi: 10.4155/fmc.14.129.
No abstract available

Keywords: edema; eicosanoid; hemorrhage; ischemia; lipoxygenase; oxidative stress; stroke; tissue plasminogen activator.

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Arachidonate 12-Lipoxygenase / chemistry*
  • Arachidonate 12-Lipoxygenase / metabolism
  • Arachidonate 15-Lipoxygenase / chemistry*
  • Arachidonate 15-Lipoxygenase / metabolism
  • Cell Line
  • Humans
  • Lipoxygenase Inhibitors / therapeutic use*
  • Mice
  • Neuroprotective Agents / pharmacology
  • Stroke / drug therapy*
  • Tissue Plasminogen Activator / metabolism

Substances

  • 12-15-lipoxygenase
  • Lipoxygenase Inhibitors
  • Neuroprotective Agents
  • Arachidonate 12-Lipoxygenase
  • Arachidonate 15-Lipoxygenase
  • Tissue Plasminogen Activator