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Appl Physiol Nutr Metab. 2015 Jan;40(1):96-8. doi: 10.1139/apnm-2014-0290.

Fasting and exercise differentially regulate BDNF mRNA expression in human skeletal muscle.

Author information

1
School of Kinesiology and Health Studies, Queen's University, Kingston, ON K7L 3N6, Canada.

Abstract

Brain-derived neurotrophic factor (BDNF) gene expression was measured in human skeletal muscle following 3 intensities of exercise and a 48-h fast. No change in BDNF mRNA was observed following exercise, while fasting upregulated BDNF by ∼ 3.5-fold. These changes were dissociated from changes in peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) following exercise (+2- to 15-fold) and fasting (∼-25%). These results challenge our understanding of the response of BDNF to energetic stress and highlight the importance of future work in this area.

KEYWORDS:

PGC-1α; energetic stress; exercice par intervalle d’intensité élevée; high-intensity interval exercise; stress énergétique

PMID:
25494871
DOI:
10.1139/apnm-2014-0290
[Indexed for MEDLINE]

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