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AIDS. 2014 Nov 28;28(18):2781-6. doi: 10.1097/QAD.0000000000000489.

Role of education and differentiation in determining the potential of natural killer cells to respond to antibody-dependent stimulation.

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aDepartment of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne bBurnet Institute, Melbourne cMelbourne Sexual Health Centre, Carlton, Victoria, Australia.


Antibody-dependent activation of natural killer (NK) cells might facilitate protective outcomes in the context of HIV exposure or infection. Antibody-dependent activation is heightened in NK cells educated by interactions between killer immunoglobulin-like receptors (KIRs) and their major histocompatibility complex class I ligands during ontogeny. Differentiated NK cells, defined as CD57, also exhibit enhanced antibody-dependent responsiveness. Although KIRs are more frequently expressed on CD57 NK cells, the presented data suggest education and differentiation make independent contributions to NK cell anti-HIV envelope antibody-dependent activation.

[Indexed for MEDLINE]

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