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PLoS One. 2014 Dec 10;9(12):e114003. doi: 10.1371/journal.pone.0114003. eCollection 2014.

Persistent Associations between Maternal Prenatal Exposure to Phthalates on Child IQ at Age 7 Years.

Author information

1
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States of America.
2
National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
3
Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, United States of America.
4
Department of Environmental Health Sciences, Columbia Center for Children's Environmental Health, Mailman School of Public Health, Columbia University, New York, New York, United States of America.
5
Heilbrunn Department of Population and Family Health, Mailman School of Public Health, Columbia University, New York, New York, United States of America.

Abstract

BACKGROUND:

Prior research reports inverse associations between maternal prenatal urinary phthalate metabolite concentrations and mental and motor development in preschoolers. No study evaluated whether these associations persist into school age.

METHODS:

In a follow up of 328 inner-city mothers and their children, we measured prenatal urinary metabolites of di-n-butyl phthalate (DnBP), butylbenzyl phthalate (BBzP), di-isobutyl phthalate (DiBP), di-2-ethylhexyl phthalate and diethyl phthalate in late pregnancy. The Wechsler Intelligence Scale for Children, 4th edition was administered at child age 7 years and evaluates four areas of cognitive function associated with overall intelligence quotient (IQ).

RESULTS:

Child full-scale IQ was inversely associated with prenatal urinary metabolite concentrations of DnBP and DiBP: b = -2.69 (95% confidence interval [CI] = -4.33, -1.05) and b = -2.69 (95% CI = -4.22, -1.16) per log unit increase. Among children of mothers with the highest versus lowest quartile DnBP and DiBP metabolite concentrations, IQ was 6.7 (95% CI = 1.9, 11.4) and 7.6 (95% CI = 3.2, 12.1) points lower, respectively. Associations were unchanged after control for cognition at age 3 years. Significant inverse associations were also seen between maternal prenatal metabolite concentrations of DnBP and DiBP and child processing speed, perceptual reasoning and working memory; DiBP and child verbal comprehension; and BBzP and child perceptual reasoning.

CONCLUSION:

Maternal prenatal urinary metabolite concentrations measured in late pregnancy of DnBP and DiBP are associated with deficits in children's intellectual development at age 7 years. Because phthalate exposures are ubiquitous and concentrations seen here within the range previously observed among general populations, results are of public health significance.

PMID:
25493564
PMCID:
PMC4262205
DOI:
10.1371/journal.pone.0114003
[Indexed for MEDLINE]
Free PMC Article

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