Format

Send to

Choose Destination
Vascular. 2015 Dec;23(6):580-5. doi: 10.1177/1708538114563824. Epub 2014 Dec 9.

Autologous platelet-rich plasma in treatment of chronic venous leg ulcers: A prospective case series.

Author information

1
Department of Cardiovascular Surgery, Hitit University Corum Education and Research Hospital, Turkey drlabarna@gmail.com.
2
Department of Cardiovascular Surgery, Hitit University Corum Education and Research Hospital, Turkey.
3
Department of Cardiovascular Surgery, Gulhane Medical Military Academy, Turkey.

Abstract

STUDY:

We report our results on a case series of 19 patients receiving platelet-rich plasma application in treatment of patients with chronic unhealing venous leg ulcers.

MATERIAL AND METHODS:

There were 16 males and three females with a mean age of 38.55 ± 16.46 years. Planimetric size measurements were performed and pain was tested throughout the treatment period. Follow-up was made in seven-day periods. Patients received 5 ml of platelet-rich plasma for each 5 cm(2) of the wound surface with half of the amount being injected 1-2 mm deep into the wound and the wound surface was covered with the remaining half.

RESULTS:

Complete wound healing occurred in 18 of 19 patients (94.7%) within a mean of 4.82 ± 2.16 week. There were significant reductions in wound area among all consecutive measurements except for first week. A significant reduction in wound volume was apparent even in first week and sustained among consecutive measurements.

CONCLUSION:

Platelet-rich plasma seems effective in terms of promoting healing of venous leg ulcers. Improvement in wound depth was slightly more prominent than that in wound area, indicating a potential role of platelet-rich plasma especially in deep venous ulcers.

KEYWORDS:

Platelet-rich plasma; chronic venous insufficiency; wound

PMID:
25492574
DOI:
10.1177/1708538114563824
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center