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Mater Sci Eng C Mater Biol Appl. 2014 Dec;45:671-81. doi: 10.1016/j.msec.2014.06.004. Epub 2014 Jun 19.

The electrically conductive scaffold as the skeleton of stem cell niche in regenerative medicine.

Author information

1
Institute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), 3 Research Link, 117602, Singapore.
2
Institute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), 3 Research Link, 117602, Singapore. Electronic address: lik@imre.a-star.edu.sg.

Abstract

Stem cells with multipotent and self-renewal abilities play a vital role in regenerative medicine and tissue engineering. They can assist tissue reconstruction through specific differentiation and secretion of various bioactive macromolecules. More and more studies confirm that the cell-fate commitment can be manipulated via constructing a specific stem cell niche. The construction of specific niches with conductive materials (conducting polymers, carbon nanotubes and graphene) can promote stem cell differentiation towards electro-active lineages and emphasize the promising role of stem cells in electro-active tissue regeneration (e.g., nerve and heart). In this review, we summarize the commonly applied conductive materials for scaffold construction and evaluate their contributions in the regeneration of electro-active tissues.

KEYWORDS:

Conductive scaffold; Stem cell niche

PMID:
25491876
DOI:
10.1016/j.msec.2014.06.004
[Indexed for MEDLINE]

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