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Diab Vasc Dis Res. 2015 Mar;12(2):111-8. doi: 10.1177/1479164114554609. Epub 2014 Dec 9.

Evaluation of body adiposity index as a predictor of aortic stiffness in multi-ethnic Asian population with type 2 diabetes.

Author information

1
Clinical Research Unit, Khoo Teck Puat Hospital, Singapore.
2
Diabetes Centre, Khoo Teck Puat Hospital, Singapore.
3
Department of Family and Community Medicine, Khoo Teck Puat Hospital, Singapore.
4
Department of Medicine, Khoo Teck Puat Hospital, Singapore.
5
National Healthcare Group Polyclinics, Singapore.
6
Diabetes Centre, Khoo Teck Puat Hospital, Singapore lim.su.chi@alexandrahealth.com.sg.

Abstract

Cardiovascular disease is the leading cause of morbidity and mortality in type 2 diabetes mellitus. We evaluated the predictive ability of the recently developed body adiposity index for aortic stiffness, an intermediate endpoint of cardiovascular disease, in a cross-sectional multi-ethnic Asian type 2 diabetes mellitus cohort (N = 1408). AS was estimated using carotid-femoral pulse wave velocity measured by applanation tonometry. Body adiposity index was computed as hip circumference/(height)(1.5) - 18. Compared to body mass index, waist circumference and visceral fat area, body adiposity index displayed the weakest association with pulse wave velocity (r = 0.077, 0.096, 0.134 and 0.058, respectively; all p < 0.05). Interestingly, the relationship between measurements of obesity and pulse wave velocity was ethnic dependent - body mass index, body adiposity index, waist circumference and visceral fat area consistently predicted pulse wave velocity only in Indians but not others. In multi-variable analysis, body mass index was a significant determinant of pulse wave velocity in all ethnicities. In conclusion, body adiposity index is a weak predictor of aortic stiffness (when compared with body mass index) in Asians with type 2 diabetes mellitus.

KEYWORDS:

Aortic stiffness; body adiposity index; obesity; type 2 diabetes

PMID:
25491287
DOI:
10.1177/1479164114554609
[Indexed for MEDLINE]

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