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Diab Vasc Dis Res. 2015 Mar;12(2):111-8. doi: 10.1177/1479164114554609. Epub 2014 Dec 9.

Evaluation of body adiposity index as a predictor of aortic stiffness in multi-ethnic Asian population with type 2 diabetes.

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Clinical Research Unit, Khoo Teck Puat Hospital, Singapore.
Diabetes Centre, Khoo Teck Puat Hospital, Singapore.
Department of Family and Community Medicine, Khoo Teck Puat Hospital, Singapore.
Department of Medicine, Khoo Teck Puat Hospital, Singapore.
National Healthcare Group Polyclinics, Singapore.
Diabetes Centre, Khoo Teck Puat Hospital, Singapore


Cardiovascular disease is the leading cause of morbidity and mortality in type 2 diabetes mellitus. We evaluated the predictive ability of the recently developed body adiposity index for aortic stiffness, an intermediate endpoint of cardiovascular disease, in a cross-sectional multi-ethnic Asian type 2 diabetes mellitus cohort (N = 1408). AS was estimated using carotid-femoral pulse wave velocity measured by applanation tonometry. Body adiposity index was computed as hip circumference/(height)(1.5) - 18. Compared to body mass index, waist circumference and visceral fat area, body adiposity index displayed the weakest association with pulse wave velocity (r = 0.077, 0.096, 0.134 and 0.058, respectively; all p < 0.05). Interestingly, the relationship between measurements of obesity and pulse wave velocity was ethnic dependent - body mass index, body adiposity index, waist circumference and visceral fat area consistently predicted pulse wave velocity only in Indians but not others. In multi-variable analysis, body mass index was a significant determinant of pulse wave velocity in all ethnicities. In conclusion, body adiposity index is a weak predictor of aortic stiffness (when compared with body mass index) in Asians with type 2 diabetes mellitus.


Aortic stiffness; body adiposity index; obesity; type 2 diabetes

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