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J Neurol. 2015;262(4):1081-95. doi: 10.1007/s00415-014-7600-8. Epub 2014 Dec 10.

Clinical and experimental studies of potentially pathogenic brain-directed autoantibodies: current knowledge and future directions.

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1
Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, West Wing, Level 6, Oxford, OX3 9DU, UK.

Abstract

The field of neuronal surface-directed antibody-mediated diseases of the central nervous system has dramatically expanded in the last few years and now forms an important cluster of treatable neurological conditions. In this review, we focus on three areas. First, we review the demographics, clinical features and treatment responses of these conditions. Second, we consider their pathophysiology and compare autoantibody mechanisms and their effects to genetic or pharmacological disruptions of the target antigens. Third, we discuss areas of controversy within the field, propose possible resolutions, and explore new directions for neuronal surface antibody-mediated diseases.

PMID:
25491076
PMCID:
PMC4412383
DOI:
10.1007/s00415-014-7600-8
[Indexed for MEDLINE]
Free PMC Article
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