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Cancer Cell. 2014 Dec 8;26(6):775-776. doi: 10.1016/j.ccell.2014.11.003.

Epigenetic noise fuels cancer evolution.

Author information

1
Cancer Research UK London Research Institute, London WC2A 3LY, UK; UCL Cancer Institute, London WC1E 6BT, UK. Electronic address: charles.swanton@cancer.org.uk.
2
UCL Cancer Institute, London WC1E 6BT, UK. Electronic address: s.beck@ucl.ac.uk.

Abstract

Cancer is a disease of the genome and the epigenome. Previous studies have shown that genomic changes such as mutations, copy number variation, and genomic rearrangements drive cancer evolution. In this issue of Cancer Cell, Landau and colleagues add epigenomic changes, specifically locally disordered DNA methylation, to cancer's evolutionary trajectory.

PMID:
25490439
DOI:
10.1016/j.ccell.2014.11.003
[Indexed for MEDLINE]
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