Format

Send to

Choose Destination
Cancer Cell. 2014 Dec 8;26(6):773-774. doi: 10.1016/j.ccell.2014.11.020.

Controlling COR competence: BCL-6 regulates neurogenesis and tumor suppression.

Author information

1
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: chin.chiang@vanderbilt.edu.
2
Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA; Department of Neurological Surgery, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: rebecca.ihrie@vanderbilt.edu.

Abstract

In this issue of Cancer Cell, Tiberi and colleagues describe a tumor-suppressor role for BCL6. In the cerebellum, BCL6 is required for the transition from proliferative precursor cell to a more differentiated immature neuron through repressing the expression of Hedgehog effectors, thus controlling a pathway that is aberrantly activated in medulloblastoma.

PMID:
25490438
DOI:
10.1016/j.ccell.2014.11.020
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center