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Dev Cell. 2014 Dec 8;31(5):525-38. doi: 10.1016/j.devcel.2014.11.006.

Cytokinetic abscission: molecular mechanisms and temporal control.

Author information

1
Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), 1030 Vienna, Austria.
2
Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), 1030 Vienna, Austria. Electronic address: daniel.gerlich@imba.oeaw.ac.at.

Abstract

Cytokinesis mediates the physical separation of dividing cells after chromosome segregation. In animal cell cytokinesis, a contractile ring, mainly composed of actin and myosin filaments, ingresses a cleavage furrow midway between the two spindle poles. A distinct machinery, involving the endosomal sorting complex required for transport III (ESCRT-III), subsequently splits the plasma membrane of nascent daughter cells in a process termed abscission. Here, we provide a brief overview of early cytokinesis events in animal cells and then cover in depth recently emerging models for the assembly and function of the abscission machinery and its temporal coordination with chromosome segregation.

PMID:
25490264
DOI:
10.1016/j.devcel.2014.11.006
[Indexed for MEDLINE]
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