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Diagn Microbiol Infect Dis. 2015 Feb;81(2):96-101. doi: 10.1016/j.diagmicrobio.2014.11.004. Epub 2014 Nov 15.

Implementation and performance of the BioFire FilmArray® Blood Culture Identification panel with antimicrobial treatment recommendations for bloodstream infections at a midwestern academic tertiary hospital.

Author information

1
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA; Nebraska Public Health Laboratory, Omaha, NE, USA. Electronic address: robbie.southern@unmc.edu.
2
Division of Infectious Disease, Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
3
Clinical Microbiology Laboratory, The Nebraska Medical Center, Omaha, NE, USA.
4
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA; Nebraska Public Health Laboratory, Omaha, NE, USA.
5
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.

Abstract

The FilmArray® Blood Culture Identification (BCID) panel was recently implemented at a midwestern academic tertiary care hospital to provide rapid identification (ID) of common pathogens from positive blood cultures. This study evaluated the clinical performance of the BCID panel compared to culture-based ID methods. One hundred thirty-eight monomicrobial and 8 polymicrobial blood cultures were evaluated during the 30-day study resulting in the ID of 152 total organisms by culture with 115 organisms correctly identified using the BCID panel. The BCID panel had sensitivities of 80.4% (115/152) for all organisms identified during the study and 94.6% (115/122) when considering only on-panel organisms. BCID panel specificity was 100%. Implementation of the BCID panel was coupled with the development of empiric therapy recommendations for bloodstream infections by the antimicrobial stewardship team. Based on this study, the FilmArray® BCID panel is a rapid and reliable test for the detection of common bloodstream pathogens, and therapeutic decisions can be based upon panel results.

KEYWORDS:

Antimicrobial recommendations; Antimicrobial stewardship; BCID; Bloodstream infection; Clinical performance; FilmArray Blood Culture Identification panel

[Indexed for MEDLINE]

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