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Acta Biochim Biophys Sin (Shanghai). 2015 Jan;47(1):16-28. doi: 10.1093/abbs/gmu110. Epub 2014 Dec 8.

The regulation and function of YAP transcription co-activator.

Author information

1
Life Sciences Institute and Innovation Center for Cell Biology, Zhejiang University, Hangzhou 310058, China.
2
Institute of Aging Research, Hangzhou Normal University, Hangzhou 311121, China binzhao@zju.edu.cn lili9981@gmail.com.
3
Life Sciences Institute and Innovation Center for Cell Biology, Zhejiang University, Hangzhou 310058, China binzhao@zju.edu.cn lili9981@gmail.com.

Abstract

The Hippo pathway was initially identified in Drosophila by genetic mosaic screens for tumor suppressor genes. Researches indicated that the Hippo pathway is a key regulator of organ size and is conserved during evolution. Furthermore, studies of mouse models and clinical samples demonstrated the importance of Hippo pathway dysregulation in human cancer development. In addition, the Hippo pathway contributes to progenitor cell and stem cell self-renewal and is thus involved in tissue regeneration. In the Hippo pathway, MST1/2 kinases together with the adaptor protein SAV phosphorylate LATS1/2 kinases. Interaction with an adaptor protein MOB is also important for LATS1/2 activation. Activated LATS1/2 in turn phosphorylate and inhibit Yes-associated protein (YAP). YAP is a key downstream effector of the Hippo pathway, and is a transcriptional co-activator that mainly interacts with TEAD family transcription factors to promote gene expression. Alteration of gene expression by YAP leads to cell proliferation, apoptosis evasion, and also stem cell amplification. In this review, we mainly focus on YAP, discussing its regulation and mechanisms of action in the context of organ size control, tissue regeneration and tumorigenesis.

KEYWORDS:

Hippo; YAP; apoptosis; cancer; organ size; proliferation

PMID:
25487920
DOI:
10.1093/abbs/gmu110
[Indexed for MEDLINE]

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