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Acta Biochim Biophys Sin (Shanghai). 2015 Jan;47(1):60-4. doi: 10.1093/abbs/gmu112. Epub 2014 Dec 8.

The non-canonical Hippo/Mst pathway in lymphocyte development and functions.

Author information

1
State Key Laboratory of Genetic Engineering and Institute of Developmental Biology and Molecular Medicine, Scholl of Life Sciences, Fudan University, Shanghai 200433, China.
2
University of Toronto, Toronto, Ontario M5S2J7, Canada.
3
State Key Laboratory of Genetic Engineering and Institute of Developmental Biology and Molecular Medicine, Scholl of Life Sciences, Fudan University, Shanghai 200433, China wufan_tao@fudan.edu.cn.

Abstract

The canonical Hippo/Mst pathway, originally discovered in Drosophila, is famous for its function in promoting apoptosis, inhibiting cell proliferation and tumorigenesis, and regulating tissue regeneration. However, emerging evidence shows that multiple non-canonical Hippo signaling pathways are also implicated in the regulation of various other biological processes. Recent studies have revealed that Mst1/2, the core kinases of Hippo/Mst pathway are required for T cell development, function, survival, trafficking, and homing, and also involved in regulation of autoimmunity. In this review, we discuss the roles of non-canonical Hippo/Mst signaling pathways in lymphocyte development and functions.

KEYWORDS:

Mst1/2; development; function; lymphocyte

PMID:
25487919
DOI:
10.1093/abbs/gmu112
[Indexed for MEDLINE]

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