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Antimicrob Agents Chemother. 2015 Feb;59(2):1356-9. doi: 10.1128/AAC.04759-14. Epub 2014 Dec 8.

Complete nucleotide sequence of the IncN plasmid encoding IMP-6 and CTX-M-2 from emerging carbapenem-resistant Enterobacteriaceae in Japan.

Author information

1
Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima City, Hiroshima, Japan Department of Bacteriology, Hiroshima University Graduate School of Biomedical Health Sciences, Hiroshima City, Hiroshima, Japan.
2
Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima City, Hiroshima, Japan Department of Bacteriology, Hiroshima University Graduate School of Biomedical Health Sciences, Hiroshima City, Hiroshima, Japan Department of Surgery I, Hiroshima University Graduate School of Biomedical Health Sciences, Hiroshima City, Hiroshima, Japan.
3
Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima City, Hiroshima, Japan Department of Bacteriology, Hiroshima University Graduate School of Biomedical Health Sciences, Hiroshima City, Hiroshima, Japan Clinical Laboratory, Hiroshima General Hospital of West Japan Railway Company, Hiroshima, Hiroshima, Japan.
4
Center for Omics and Bioinformatics, The Department of Computational Biology, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.
5
Department of Plant Genome Research, Kazusa DNA Research Institute, Kisarazu, Chiba, Japan.
6
Inserm U1092, Faculté de Médecine, Limoges, France.
7
Clinical Laboratory, Shiga Medical Center for Adults, Moriyama, Shiga, Japan.
8
Department of Clinical Laboratory, Wakayama Rosai Hospital, Wakayama, Japan.
9
Clinical Laboratory, Hyogo Medical University Hospital, Nishinomiya, Hyogo, Japan.
10
Hyogo Prefectural Amagasaki Hospital, Amagasaki City, Hyogo, Japan.
11
Department of Surgery I, Hiroshima University Graduate School of Biomedical Health Sciences, Hiroshima City, Hiroshima, Japan.
12
Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima City, Hiroshima, Japan Clinical Laboratory, Hiroshima University Hospital, Hiroshima City, Hiroshima, Japan.
13
Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima City, Hiroshima, Japan Department of Infectious Diseases, Hiroshima University Hospital, Hiroshima City, Hiroshima, Japan.
14
Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima City, Hiroshima, Japan Department of Bacteriology, Hiroshima University Graduate School of Biomedical Health Sciences, Hiroshima City, Hiroshima, Japan sugai@hiroshima-u.ac.jp/

Abstract

We have determined the DNA sequence of Klebsiella pneumoniae multidrug resistance plasmid pKPI-6, which is a self-transmissible IncN-type plasmid. pKPI-6 harboring blaIMP-6 and blaCTX-M-2 confers a stealth-type carbapenem resistance phenotype on members of the family Enterobacteriaceae that is not detectable with imipenem. pKPI-6 is already epidemic in Japan, favoring the dissemination of IMP-6 and CTX-M-2 in members of the family Enterobacteriaceae.

PMID:
25487806
PMCID:
PMC4335907
DOI:
10.1128/AAC.04759-14
[Indexed for MEDLINE]
Free PMC Article

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