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Philos Trans R Soc Lond B Biol Sci. 2015 Jan 19;370(1660):20130376. doi: 10.1098/rstb.2013.0376.

A new era in palaeomicrobiology: prospects for ancient dental calculus as a long-term record of the human oral microbiome.

Author information

1
Department of Anthropology, University of Oklahoma, Norman, OK, USA christina.warinner@ou.edu.
2
Department of Archaeology, University of York, York, UK.

Abstract

The field of palaeomicrobiology is dramatically expanding thanks to recent advances in high-throughput biomolecular sequencing, which allows unprecedented access to the evolutionary history and ecology of human-associated and environmental microbes. Recently, human dental calculus has been shown to be an abundant, nearly ubiquitous, and long-term reservoir of the ancient oral microbiome, preserving not only microbial and host biomolecules but also dietary and environmental debris. Modern investigations of native human microbiota have demonstrated that the human microbiome plays a central role in health and chronic disease, raising questions about changes in microbial ecology, diversity and function through time. This paper explores the current state of ancient oral microbiome research and discusses successful applications, methodological challenges and future possibilities in elucidating the intimate evolutionary relationship between humans and their microbes.

KEYWORDS:

ancient DNA; dental calculus; metagenomics; metaproteomics; oral microbiome; palaeomicrobiology

PMID:
25487328
PMCID:
PMC4275884
DOI:
10.1098/rstb.2013.0376
[Indexed for MEDLINE]
Free PMC Article

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