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Trends Mol Med. 2015 Jan;21(1):6-15. doi: 10.1016/j.molmed.2014.11.001. Epub 2014 Nov 15.

Pediatric small intestine bacterial overgrowth in low-income countries.

Author information

  • 1Division of Pediatric Infectious Diseases, Children's Hospital of Richmond, Richmond, VA 23298, USA.
  • 2Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: wap3g@virginia.edu.

Abstract

Small intestine bacterial overgrowth (SIBO) occurs when colonic quantities of commensal bacteria are present in the small bowel. SIBO is associated with conditions of disrupted gastrointestinal (GI) motility leading to stasis of luminal contents. Recent data show that SIBO is also found in children living in unsanitary conditions who do not have access to clean water. SIBO leads to impaired micronutrient absorption and increased GI permeability, both of which may contribute to growth stunting in children. SIBO also disrupts mucosal immunity and has been implicated in oral vaccination underperformance and the development of celiac disease. SIBO in the setting of the impoverished human habitats may be an under-recognized cause of pediatric morbidity and mortality in the developing world.

KEYWORDS:

celiac disease; commensal bacteria; environmental enteropathy; malnutrition; oral vaccine failure; small intestine bacterial overgrowth

PMID:
25486880
PMCID:
PMC4402728
DOI:
10.1016/j.molmed.2014.11.001
[PubMed - indexed for MEDLINE]
Free PMC Article
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