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Nat Neurosci. 2015 Jan;18(1):66-74. doi: 10.1038/nn.3891. Epub 2014 Dec 8.

Retinal output changes qualitatively with every change in ambient illuminance.

Author information

1
Retinal Circuits and Optogenetics, Centre for Integrative Neuroscience and Bernstein Center for Computational Neuroscience, University of Tübingen, Germany.
2
Current address: Dept. of Neurosurgery and Hansen Experimental Physics Laboratory, Stanford University, Stanford CA 94305, USA.
3
Faculty of Life Science, University of Manchester, Manchester M13 9PT, United Kingdom.
4
Department for General, Visceral and Transplant Surgery, Institute for Experimental Surgery, University Hospital Tübingen, Germany.
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Contributed equally

Abstract

The collective activity pattern of retinal ganglion cells, the retinal code, underlies higher visual processing. How does the ambient illuminance of the visual scene influence this retinal output? We recorded from isolated mouse and pig retina and from mouse dorsal lateral geniculate nucleus in vivo at up to seven ambient light levels covering the scotopic to photopic regimes. Across each luminance transition, most ganglion cells exhibited qualitative response changes, whereas they maintained stable responses within each luminance. We commonly observed the appearance and disappearance of ON responses in OFF cells and vice versa. Such qualitative response changes occurred for a variety of stimuli, including full-field and localized contrast steps and naturalistic movies. Our results suggest that the retinal code is not fixed but varies with every change of ambient luminance. This finding raises questions about signal processing within the retina and has implications for visual processing in higher brain areas.

Comment in

PMID:
25485757
PMCID:
PMC4338531
DOI:
10.1038/nn.3891
[Indexed for MEDLINE]
Free PMC Article

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