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Indian J Dermatol. 2014 Nov;59(6):630. doi: 10.4103/0019-5154.143567.

Evaluation of Serum Homocysteine, High-Sensitivity CRP, and RBC Folate in Patients with Alopecia Areata.

Author information

1
Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2
Conjoint Faculty Member, University of New South Wales, Sydney, Australia.
3
Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Abstract

INTRODUCTION:

Alopecia areata (AA) is a common type of hair loss with an autoimmune basis. As the role of homocysteine (Hcys), folate, and CRP has been considered in some autoimmune diseases.

OBJECTIVES:

To evaluate homocysteine, folate and CRP level in AA.

METHODS:

This study was performed on 29 patients who had AA for at least 6 months affecting more than 20% of scalp, and 32 healthy controls. Levels of serum Hcys, blood high-sensitivity CRP, and RBC folate were measured in all subjects.

RESULTS:

The mean level of RBC folate was significantly lower in the patient group than that in controls (P < 0.001). Also, the level of RBC folate was significantly lower in patients with extensive forms of disease (alopecia totalis/alopecia universalis) in comparison with more localized form (patchy hair loss) (P < 0.05). Patients with higher "Severity of Alopecia Total" (SALT) score had lower RBC folate, as well. Serum Hcys and blood high-sensitivity CRP levels did not show a significant difference in two groups.

CONCLUSION:

Patients with alopecia areata have lower level of RBC folate which is in negative correlation with both severity and extension of AA.

KEYWORDS:

Alopecia areata; C-reactive protein; folate; homocysteine

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