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Acta Physiol (Oxf). 2015 Feb;213(2):321-33. doi: 10.1111/apha.12432. Epub 2014 Dec 29.

Interactions of the orexin/hypocretin neurones and the histaminergic system.

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1
Institute of Biomedicine, Anatomy, and Neuroscience center, University of Helsinki, Helsinki, Finland.

Abstract

Histaminergic and orexin/hypocretin systems are components in the brain wake-promoting system. Both are affected in the sleep disorder narcolepsy, but the role of histamine in narcolepsy is unclear. The histaminergic neurones are activated by the orexin/hypocretin system in rodents, and the development of the orexin/hypocretin neurones is bidirectionally regulated by the histaminergic system in zebrafish. This review summarizes the current knowledge of the interactions of these two systems in normal and pathological conditions in humans and different animal models.

KEYWORDS:

autoimmune; histamine; hypocretin/orexin; mouse; narcolepsy; zebrafish

PMID:
25484194
DOI:
10.1111/apha.12432
[Indexed for MEDLINE]
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