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Virology. 1989 Aug;171(2):637-9.

Detection of a trypsin-like serine protease domain in flaviviruses and pestiviruses.

Author information

1
Department of Biophysics, University of California, Berkeley 94720.

Abstract

We propose through a sequence and structural-pattern analysis that a protein domain of undefined function encoded by the enveloped RNA flavi- and pestivruses is a Ser active-center enzyme related to the cellular trypsin family. A further homology is emphasized with the group of (Cys active-center) viral proteases encoded by nonenveloped RNA viruses of the picorna-, como-, nepo-, and potyvirus classes. Structural modeling of the putative flaviviral protease domain suggests amino acids that are crucial for catalytic activity and substrate binding.

PMID:
2548336
DOI:
10.1016/0042-6822(89)90639-9
[Indexed for MEDLINE]

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