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Gut Microbes. 2014;5(6):761-5. doi: 10.4161/19490976.2014.972238.

Antimicrobial peptides and the enteric mucus layer act in concert to protect the intestinal mucosa.

Author information

1
a Institute of Medical Microbiology and Hospital Epidemiology; Hannover Medical School ; Hannover , Germany.

Abstract

The intestinal mucosa squares the circle by allowing efficient nutrient absorption while generating a firm barrier toward the enteric microbiota, enteropathogenic microorganisms and high luminal concentrations of potent immunostimulatory molecules. The mucus layer together with local antimicrobial and anti-inflammatory peptides significantly contribute to this ability. Here we summarize the recent progress made to better understand the critical importance of this dynamic, complex and highly structured anti-inflammatory and antimicrobial barrier.

KEYWORDS:

CRS, Cryptdin-related sequence; HD, Human defensin; IAP, Intestinal alkaline phosphatase; LBP, Lipopolysaccharide binding protein; RegIII╬│, Regenerating islet-derived protein 3 ╬│; SIgA, Secretory immunoglobulin A.; antimicrobial peptides; host-microbial homeostasis; intestine; microbiota; mucosal host defense; mucus layer; paneth cells

PMID:
25483327
PMCID:
PMC4615892
DOI:
10.4161/19490976.2014.972238
[Indexed for MEDLINE]
Free PMC Article

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