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Sci Rep. 2014 Dec 8;4:7351. doi: 10.1038/srep07351.

T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility.

Author information

1
Lebanese American University, School of Medicine, Beirut 1102 2801, Lebanon.
2
Shafallah Medical Genetics Center, Doha, Qatar.
3
Centre Hospitalier du Nord-CHN, Zgharta, Lebanon.
4
1] Lebanese American University, School of Medicine, Beirut 1102 2801, Lebanon [2] University Medical Center - Rizk Hospital (UMC-RH), Lebanon.
5
INSERM, UMRS872, Centre de Recherche des Cordeliers, Paris, France.
6
Bioinformatics and Pattern Discovery, IBM T. J. Watson Research Centre, Yorktown Hgts, NY 10598, USA.
7
1] Shafallah Medical Genetics Center, Doha, Qatar [2] University of Iowa Carver College of Medicine, Iowa City.
8
1] Lebanese American University, School of Medicine, Beirut 1102 2801, Lebanon [2] Harvard School of Public Health, Boston MA 02215, USA.

Abstract

Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are crucial to the understanding of Type 2 Diabetes Mellitus (T2DM) pathophysiology. We report a GWAS on the genetic basis of T2DM in a 3,286 Lebanese participants. More than 5,000,000 SNPs were directly genotyped or imputed using the 1000 Genomes Project reference panels. We identify genome-wide significant variants in two loci CDKAL1 and TCF7L2, independent of sex, age and BMI, with leading variants rs7766070 (OR = 1.39, P = 4.77 × 10(-9)) and rs34872471 (OR = 1.35, P = 1.01 × 10(-8)) respectively. The current study is the first GWAS to find genomic regions implicated in T2DM in the Lebanese population. The results support a central role of CDKAL1 and TCF7L2 in T2DM susceptibility in Southwest Asian populations and provide a plausible component for understanding molecular mechanisms involved in the disease.

PMID:
25483131
PMCID:
PMC5376673
DOI:
10.1038/srep07351
[Indexed for MEDLINE]
Free PMC Article

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