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Sci Rep. 2014 Dec 8;4:7348. doi: 10.1038/srep07348.

Stability of gut enterotypes in Korean monozygotic twins and their association with biomarkers and diet.

Author information

1
Department of Environmental Health, Graduate School of Public Health, Seoul National University, Gwanak-gu, Seoul, Republic of Korea.
2
Division of Computer Science and Engineering, College of Engineering, Hanyang University, Seongdong-gu, Seoul, Republic of Korea.
3
Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-Gu, Seoul, Republic of Korea.
4
Department of Family Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan Jin-Gu, Busan, Republic of Korea.
5
Department of Epidemiology, Graduate School of Public Health, Seoul National University, Gwanak-gu, Seoul, Republic of Korea.
6
1] Department of Environmental Health, Graduate School of Public Health, Seoul National University, Gwanak-gu, Seoul, Republic of Korea [2] Center for Human and Environmental Microbiome, Seoul National University, Gwanak-gu, Seoul, Republic of Korea [3] N-Bio, Seoul National University, Gwanak-gu, Seoul, Republic of Korea.

Abstract

Studies on the human gut microbiota have suggested that human individuals could be categorized into enterotypes based on the compositions of their gut microbial communities. Here, we report that the gut microbiota of healthy Koreans are clustered into two enterotypes, dominated by either Bacteroides (enterotype 1) or Prevotella (enterotype 2). More than 72% of the paired fecal samples from monozygotic twin pairs were assigned to the same enterotype. Our longitudinal analysis of these twins indicated that more than 80% of the individuals belonged to the same enterotype after about a 2-year interval. Microbial functions based on KEGG pathways were also divided into two clusters. For enterotype 2, 100% of the samples belonged to the same functional cluster, while for enterotype 1, approximately half of the samples belonged to each functional cluster. Enterotype 2 was significantly associated with long-term dietary habits that were high in dietary fiber, various vitamins, and minerals. Among anthropometrical and biochemical traits, the level of serum uric acid was associated with enterotype. These results suggest that host genetics as well as host properties such as long-term dietary patterns and a particular clinical biomarker could be important contributors to the enterotype of an individual.

PMID:
25482875
PMCID:
PMC4258686
DOI:
10.1038/srep07348
[Indexed for MEDLINE]
Free PMC Article

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