Format

Send to

Choose Destination
Hematol Oncol Stem Cell Ther. 2015 Mar;8(1):6-9. doi: 10.1016/j.hemonc.2014.11.005. Epub 2014 Nov 29.

THPO-MPL pathway and bone marrow failure.

Author information

1
Department of Genetics, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia; Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: madasouki@kfshrc.edu.sa.
2
Department of Anatomy & Cell Biology, University of Kansas Medical Center, Kansas City, KS, USA.
3
Adult Hematology/Bone Marrow Transplantation, Oncology Center, MBC-64, King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia.

Abstract

Single or multilineage bone marrow failure can be a serious health problem caused by hereditary and non-hereditary causes such as exposure to drugs or environmental toxins. Normal hematopoiesis requires the integrity of several pathways including the THPO-MPL pathway. Over the last two decades, significant advances in the understanding of normal and abnormal functions of this and related pathways have led to novel diagnostic and therapeutic options.

KEYWORDS:

Aplastic anemia; Bone marrow failure; CALR (calreticulin); Eltrombopag; JAK (Janus Kinase); MPL (myeloproliferative leukemia virus); Myelofibrosis; Romiplostim; THPO (Thrombopoietin); Thrombocythemia

PMID:
25482588
DOI:
10.1016/j.hemonc.2014.11.005
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center