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Toxicol Lett. 2015 Jan 22;232(2):475-80. doi: 10.1016/j.toxlet.2014.12.001. Epub 2014 Dec 3.

Inhalation of fine particulate matter during pregnancy increased IL-4 cytokine levels in the fetal portion of the placenta.

Author information

1
University of São Paulo, School of Medicine, Laboratory of Renal Physiopathology, SP, Brazil.
2
Laboratory of Cellular, Genetics and Molecular Nephrology - Department of Internal Medicine, SP, Brazil.
3
Laboratory of Experimental Air Pollution, Department of Pathology, SP, Brazil.
4
University of São Paulo, School of Medicine, Laboratory of Renal Physiopathology, SP, Brazil. Electronic address: jheimann@usp.br.

Abstract

This study aimed to verify the development of placental and systemic inflammation in rats exposed to fine particulate matter before or during pregnancy. Wistar rats were exposed to filtered air (control) or to a load of 600 μg/m(3) of fine particles in the air. The gene expression of IL-1β, IL-4, IL-6, IL-10, INF-γ, TNF-α and Toll-like receptor 4 in the placenta was evaluated. The serum and placental concentrations of IL-1β, IL-4, IL-6, IL-10, INF-γ and TNF-α were measured. The total and differential blood leukocyte and blood platelet count was assessed. Compared to control animals, IL-4 content was elevated in the fetal portion of the placenta in rats exposed to air pollution before and during pregnancy. Increased IL-4 suggests that a placental inflammatory reaction may have occurred in response to exposure to fine particulate matter and that this cytokine was responsible, among possibly others factors, for resolution of the inflammatory reaction.

KEYWORDS:

Air pollution; Decidua; Inflammation; Placenta and pregnancy

PMID:
25481569
DOI:
10.1016/j.toxlet.2014.12.001
[Indexed for MEDLINE]
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