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Bioinformatics. 2015 Apr 15;31(8):1293-5. doi: 10.1093/bioinformatics/btu803. Epub 2014 Dec 4.

GenomeCons: a web server for manipulating multiple genome sequence alignments and their consensus sequences.

Author information

1
Medical Institute of Bioregulation, Kyushu University and CREST, Japan Science and Technology Agency, 812-8582 Fukuoka, Japan Medical Institute of Bioregulation, Kyushu University and CREST, Japan Science and Technology Agency, 812-8582 Fukuoka, Japan.

Abstract

Genome sequence alignments provide valuable information on many aspects of molecular biological processes. In this study, we developed a web server, GenomeCons, for manipulating multiple genome sequence alignments and their consensus sequences for high-throughput genome sequence analyses. This server facilitates the visual inspection of multiple genome sequence alignments for a set of genomic intervals at a time. This allows the user to examine how these sites are evolutionarily conserved over time for their functional importance. The server also reports consensus sequences for the input genomic intervals, which can be applied to downstream analyses such as the identification of common motifs in the regions determined by ChIP-seq experiments.

AVAILABILITY AND IMPLEMENTATION:

GenomeCons is freely accessible at http://bioinfo.sls.kyushu-u.ac.jp/genomecons/

CONTACT:

mikita@bioreg.kyushu-u.ac.jp.

PMID:
25480378
DOI:
10.1093/bioinformatics/btu803
[Indexed for MEDLINE]

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