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Cell. 2014 Dec 4;159(6):1263-76. doi: 10.1016/j.cell.2014.11.006.

Metabolic control of autophagy.

Author information

1
Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France; INSERM, U1138, 75006 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 75005 Paris, France; Université Pierre et Marie Curie, 75005 Paris, France; Gustave Roussy Cancer Campus, 94805 Villejuif, France.
2
Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France; INSERM, U1138, 75006 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 75005 Paris, France; Université Pierre et Marie Curie, 75005 Paris, France; Gustave Roussy Cancer Campus, 94805 Villejuif, France; Université Paris Sud, 94805 Villejuif, France.
3
Center for Autophagy Research, Department of Internal Medicine, Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75690, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
4
Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France; INSERM, U1138, 75006 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 75005 Paris, France; Université Pierre et Marie Curie, 75005 Paris, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, 75015 Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, 94805 Villejuif, France. Electronic address: kroemer@orange.fr.

Abstract

Macroautophagy (herein referred to as autophagy) is an evolutionarily conserved mechanism of adaptation to adverse microenvironmental conditions, including limited nutrient supplies. Several sensors interacting with the autophagic machinery have evolved to detect fluctuations in key metabolic parameters. The signal transduction cascades operating downstream of these sensors are highly interconnected to control a spatially and chronologically coordinated autophagic response that maintains the health and function of individual cells while preserving organismal homeostasis. Here, we discuss the physiological regulation of autophagy by metabolic circuitries, as well as alterations of such control in disease.

PMID:
25480292
PMCID:
PMC4500936
DOI:
10.1016/j.cell.2014.11.006
[Indexed for MEDLINE]
Free PMC Article

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