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Int J Biochem Cell Biol. 2015 Feb;59:111-5. doi: 10.1016/j.biocel.2014.11.007. Epub 2014 Dec 3.

Rho family GTPases: making it to the third dimension.

Author information

1
University of Wisconsin-Madison, United States.
2
University of Wisconsin-Madison, United States. Electronic address: pjkeely@wisc.edu.

Abstract

The role of Rho family GTPases in controlling the actin cytoskeleton and thereby regulating cell migration has been well studied for cells migrating on 2D surfaces. In vivo, cell migration occurs within three-dimensional matrices and along aligned collagen fibers with rather different spatial requirements. Recently, a handful of studies coupled with new approaches have demonstrated that Rho GTPases have unique regulation and roles during cell migration within 3D matrices, along collagen fibers, and in vivo. Here we propose that migration on aligned matrices facilitates spatial organization of Rho family GTPases to restrict and stabilize protrusions in the principle direction of alignment, thereby maintaining persistent migration. The result is coordinated cell movement that ultimately leads to higher rates of metastasis in vivo.

KEYWORDS:

3D extracellular matrix; Cell migration; Matrix alignment; Metastasis; Rho GTPases

PMID:
25478651
PMCID:
PMC4344808
DOI:
10.1016/j.biocel.2014.11.007
[Indexed for MEDLINE]
Free PMC Article

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